Archive for April, 2015
Historic Artefacts, Secret Messages and Code Breakers, Undercover Organisms & Organelles and Diplomatic Relationships; Inside the World of Mucosal Immunology, Health and Disease.
As complex organisms surviving in a world of molecular and physical challenges our long ancestry has meant we have evolved a remarkably complex system of defence and repair. Regular insults have played a major role in natural selection traits and diverse defence mechanisms have evolved to support our survival and reproduction in the face of substantive risk.
The result is our beautiful, intricate and complex immune system, in which we have developed two primary structural divisions, one that is encoded through our genes (germ line encoded: innate) and needs little or no education to be up and running and one that requires coercion, education and evolution (adaptive: cellular and humoral) to provide us with an exquisite and contextual set of defensive capabilities and enduring molecular memories. Read the rest of this entry »
A Meta-Analysis of the Utility of C-Reactive Protein, Erythrocyte Sedimentation Rate, Faecal Calprotectin, and Faecal Lactoferrin to Exclude Inflammatory Bowel Disease in Adults With IBS.
A paper in the American Journal of Gastroenterology looks at various markers to see if it is possible to use them to differentiate between IBS and IBD.
Irritable bowel syndrome (IBS) is viewed as a diagnosis of exclusion by most providers. The aim of our study was to perform a systematic review and meta-analysis to evaluate the utility of C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), faecal calprotectin, and faecal lactoferrin to distinguish between patients with IBS and inflammatory bowel disease (IBD) and healthy controls (HCs). Read the rest of this entry »